Chlorogenic acid

Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound^[1][2][3]. In Vitro: Chlorogenic acid (10 μM, 16 h) decreases HIF-1α protein levels in CoCl₂ induced hypoxic A549 cells, but does not affect HIF-1α mRNA level^[1].
Chlorogenic acid (10 μM, 24 h) inhibits the hypoxia-induced HUVEC cell migration, invasion and tube formation of vascular endothelial cells^[1].
Chlorogenic acid (25, 50 μM, 24 h) inhibits cell proliferation of Huh7 cells, and reduces the number of invading and migrating cells^[4].
In Vivo: Chlorogenic acid (10 μM, s.c.) inhibits VEGF (200 ng/mL)-induced angiogenesis in C57BL/6J mice, by suppression of AKT activation (Matrigel plug assay)^[1].
Chlorogenic acid (10-100 mg/kg, p.o.) shows protective effects against experimental reflux esophagitis in rats^[3].
Chlorogenic acid (10 mg/kg, i.v.) prevents endotoxic mortality and induced TNF-α release of LPS-intoxicated C57BL/6 mice, and ameliorates acute liver injury of LPS/GalN-challenged mice^[2].
Chlorogenic acid (ip, 25-200 mg/kg) inhibits tumor growth in NOD/SCID mice inoculated with Huh7 or H446 cells^[4].