H-Glu(OtBu)-OtBu (hydrochloride)
CAS No. : 32677-01-3
| Size | Price | Stock |
|---|---|---|
| 10g | $13 | In-stock |
| 25g | $17 | In-stock |
| 100g | $35 | In-stock |
| 500g | $174 | In-stock |
| 1000g | $347 | In-stock |
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| Cat. No. : | HY-20167A |
| M.Wt: | 295.80 |
| Formula: | C13H26ClNO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
H-Glu(OtBu)-OtBu hydrochloride is a key intermediate that can be used to synthesize prostate-specific membrane antigen (PSMA) targeting probes. H-Glu(OtBu)-OtBu hydrochloride can reduce nonspecific background binding through negatively charged linkers, improve tumor/background contrast, and can be used in prostate cancer PET/SPECT imaging studies[1]. IC50 & Target:Substance P[1] In Vivo: H-Glu (OtBu)-OtBu hydrochloride can be used to synthesize PSMA probe 5, which was then labeled with 18F under Al catalysis for tumor imaging (radioactive probe [Al18F]5). [Al18F]5 (0.3-0.4 mCi; 1 hour after injection) shows PC3-PIP tumor uptake of 4.6% ID/g in PET imaging experiments, with a background as low as 0.04% ID/g[2].
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