2-Thenoyltrifluoroacetone
CAS No. : 326-91-0
(Synonyms: HTTA; TTA; TTFA)
| Size | Price | Stock |
|---|---|---|
| 25g | $13 | In-stock |
| 100g | $36 | In-stock |
| 500g | $133 | In-stock |
| 1000g | $265 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-D0190 |
| M.Wt: | 222.19 |
| Formula: | C8H5F3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases[1][2][3].
IC50 & Target:IC50: 51.5 μM (mitochondrial electron transport chain)[1].
IC50: 0.54 μM (carboxylesterase)[4].
In Vitro:2-Thenoyltrifluoroacetone (100-1000μM, 24 h) increases mitochondrial ROS production and induces microglial cell activation by inhibiting mitochondrial electron transport chain[1].
2-Thenoyltrifluoroacetone (28.2-51.5 μM, 72 h) exhibits cytotoxicity and anticancer activity on K562 cells by forming a complex with copper (II) [2].
2-Thenoyltrifluoroacetone (500, 750, 1000 ng/mL, 24, 48, 72 h) exhibits cytotoxicity and anti-tumor activity against MCF-7 and MKN-45 cells by forming a complex with zinc (II) [3].
2-Thenoyltrifluoroacetone (1-25 μM, 20 min) significantly inhibits carboxylesterase activity in rat plasma and mitochondria [4].
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