L67
CAS No. : 325970-71-6
(Synonyms: DNA Ligase Inhibitor)
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $88 | In-stock |
| 50mg | $198 | In-stock |
| 100mg | $308 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15586 |
| M.Wt: | 486.11 |
| Formula: | C16H14Br2N4O4 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC50 are 10 μM). L67 can cause nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS. L67 also activates the Caspase 1-dependent apoptosis pathway in cancer cells, can be used in cancer research[1][2].
In Vitro:L67 (10, 15 μM; 24 h) promotes nuclear DNA damage and (0-50 μM) increases the level of mSOX by inhibiting mitochondrial LigIIIα in HeLa cells[1].
L67 (10 μM; 24 h) induces changes in mitochondrial function that cause a reduction in OCR and mitochondrial DNA, and abnormal mitochondrial morphology in HeLa[1].
L67 (10, 100 μM; 24 h) induces apoptosis in cancer cells[1].
L67 (0-30 μM; 24 h) selectively induces cell death in cancer cells by activating a caspase 1-dependent apoptotic pathway[1].
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