ICA 110381
CAS No. : 325457-99-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $70 | In-stock |
| 25mg | $120 | In-stock |
| 50mg | $175 | In-stock |
| 100mg | $245 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108587 |
| M.Wt: | 267.11 |
| Formula: | C12H8Cl2N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
ICA 110381 is an orally active Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator with anticonvulsive properties. ICA 110381 is a KCNQ2/Q3 activator (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].
IC50 & Target:EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[1]
IC50: 15 μM (KCNQ1)[1]
In Vitro:ICA 110381 induces rubidium efflux in an agonist-induced rubidium efflux assay using CHO cells expressing KCNQ2 or KCNQ3 (EC50 = 0.38 µM). ICA 110381 inhibits rubidium efflux from CHO cells expressing KCNQ1 (EC50 = 15 µM)[1].
In CA1 pyramidal cells, the increase of M-currents (IM) in the presence of ICA 110381 resulted in a damping of neuronal excitability by reducing the input resistance and shifting the resting membrane potential in hyperpolarizing direction[2].
In Vivo:ICA 110381 (3-30 mg/kg; p.o.; once) elevates the threshold for induction of afterdischarges and reduced seizure severity and duration in fully amygdala-kindled rats[2].
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