Oxfenicine
CAS No. : 32462-30-9
(Synonyms: L-p-Hydroxyphenylglycine; 4-Hydroxy-L-phenylglycine; UK 25842)
| Size | Price | Stock |
|---|---|---|
| 25g | $38 | In-stock |
| 100g | $150 | In-stock |
| 500g | $620 | Get quote |
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| Cat. No. : | HY-W018026 |
| M.Wt: | 167.16 |
| Formula: | C8H9NO3 |
| Purity: | >98 % |
| Solubility: | H2O : 4.55 mg/mL (ultrasonic);DMSO : < 1 mg/mL (ultrasonic) |
Oxfenicine (L-p-Hydroxyphenylglycine) is an orally active carnitine palmitoyltransferase-1 inhibitor. Oxfenicine inhibits the oxidation of fatty acids in the heart, protecting cardiac tissue from necrotic damage during ischemia, and also has an inhibitory effect on cardiac tissue apoptosis. In addition, Oxfenicine promotes lipolysis in a high-fat diet rat model. Oxfenicine can be used in the study of cardiovascular and metabolic diseases[1][2][3][4][5]. IC50 & Target:carnitine palmitoyltransferase-1[1] In Vitro: Oxfenicine (1 mM, 2 hours) reduces fatty acid oxidation and glucose incorporation into lipids in subcutaneous and epididymal adipocytes[4]. Oxfenicine (10 mM, 24 hours) blunts carnitine plus palmitate-induced formation of apoptotic nuclei in chick embryonic ventricular cells[5]. In Vivo: Oxfenicine (150 mg/kg, i.p., once daily for 3 weeks) treatment significantly reduces adiposity in high-fat diet rats[4].
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