RNF5 inhibitor inh-02
CAS No. : 324579-65-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $230 | In-stock |
| 10mg | $400 | In-stock |
| 25mg | $850 | In-stock |
| 50mg | $1450 | In-stock |
| 100mg | $2500 | In-stock |
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| Cat. No. : | HY-123967 |
| M.Wt: | 384.50 |
| Formula: | C23H20N4S |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C) |
RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 rescues F508del-CFTR function in F508del-CFTR-expressing immortalized cells (CFBE41o⁻, EC50 = 2.6 μM; FRT, EC 50 = 2.2 μM). RNF5 inhibitor inh-02 increases LC3IIB expression and autophagic vacuole number via reducing ATG4B ubiquitylation and promotes cell motility. RNF5 inhibitor inh-02 can be used for the study of cystic fibrosis[1].
In Vitro:RNF5 inhibitor inh-02 (2-10 μM, 24 h) significantly reduces F508del-CFTR ubiquitylation and rescues F508del-CFTR activity (EC50 = 2.6 μM) in CFBE41o- cells stably expressing F508del-CFTR and HS-YFP[1].
RNF5 inhibitor inh-02 (1-10 μM, 24 h) dose-dependently rescues F508del-CFTR activity in F508del-CFTR/HS-YFP-expressing FRT cells with an EC50 of 2.2 μM, and increases CFTR-dependent transepithelial conductance[1].
RNF5 inhibitor inh-02 (5 μM, 24 h) significantly increases CFTR-mediated transepithelial conductance, equivalent short-circuit current and chloride secretion in primary bronchial epithelial cells[1].
RNF5 inhibitor inh-02 (5 μM, 24 h) reduces ATG4B ubiquitylation, increases LC3IIB expression and autophagic vacuole number in CFBE41o- cells[1].
RNF5 inhibitor inh-02 (5 μM, 24 h) promotes cell migration and accelerates scratch gap filling in CFBE41o- cells[1].
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