T-0156


CAS No. : 324572-93-2

324572-93-2
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Cat. No. : HY-105349
M.Wt: 620.05
Formula: C31H30ClN5O7
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 324572-93-2 :

T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 enhances the nitric oxide (NO)/cGMP pathway[1]. In Vitro: T-0156 at 10 and 100 nM increases cGMP levels, causing relaxation of the tissue in the isolated rabbit corpus cavernosum[1].

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