Medifoxamine

Medifoxamine is an orally active monoamine reuptake inhibitor and antidepressant. Medifoxamine preferentially inhibits presynaptic dopamine reuptake. Medifoxamine acts as an intraocular pressure-lowering agent to reduce intraocular pressure, and also functions as a miotic agent to decrease pupil diameter. Medifoxamine exhibits characteristic properties of antidepressant compounds, including preventing hypothermia induced by Reserpine (HY-N0480) or Apomorphine (HY-12723), potentiating the toxic effects of Yohimbine (HY-N0127) in mice, and reducing immobility behavior in mice and rats in the "behavioral despair" model. Medifoxamine has no anticholinergic activity. Medifoxamine can be used in research related to depression^[1][2]. In Vivo:Medifoxamine shows no anticholinergic activity in animal models^[2].
Medifoxamine exhibits the characteristic properties of antidepressant compounds, including: preventing hypothermia induced by Reserpine (HY-N0480) or Apomorphine (HY-12723); potentiating the toxic effect of Yohimbine (HY-N0127) in mice; and reducing immobility behavior in mice and rats in the "behavioral despair" model^[2].