AGN 194078
CAS No. : 321995-62-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $630 | In-stock |
| 25mg | $1200 | In-stock |
| 50mg | $1900 | In-stock |
| 100mg | $2850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100273 |
| M.Wt: | 403.42 |
| Formula: | C22H23F2NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. IC50 & Target:Kd: 4 nM (RARα)[1] EC50: 140 nM (RARα)[1] In Vitro: AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a Kd value of 3 nM, while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activated RARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested[1].
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