10(E)-Pentadecenoic acid

10 (E)-Pentadecenoic acid (trans-10-Pentadecenoic acid) is a melanin synthesis inhibitor. 10 (E)-Pentadecenoic acid inhibits nuclear translocation and reduces the protein level of phosphorylated microphthalmia-associated transcription factor (MITF), as well as decreases intracellular tyrosinase activity. 10 (E)-Pentadecenoic acid can be used in the research of skin pigmentation disorders^[1]. In Vitro:10(E)-Pentadecenoic acid (1-60 μM; 10 min) exhibits dose-dependent copper ion reduction capacity, as measured by the CUPRAC assay, with the highest activity at 60 μM^[1].
10(E)-Pentadecenoic acid (1-60 μM; 20 min) only slightly inhibits mushroom tyrosinase activity at 1 μM, with no significant inhibition at higher concentrations (5, 15, 60 μM)^[1].
10(E)-Pentadecenoic acid (1-100 μM; 24 h) is non-cytotoxic to Hs68 human dermal fibroblast cells at concentrations up to 100 μM, but shows cytotoxicity to B16F10 murine melanoma cells at ≥50 μM and to HaCaT human keratinocyte cells at 100 μM^[1].
10(E)-Pentadecenoic acid (1-15 μM; 1 h pre-incubation, followed by 6 days co-incubation with 500 nM α-MSH) dose-dependently reduces α-MSH-stimulated melanin production in B16F10 murine melanoma cells at concentrations of 1, 5, and 15 μM^[1].
10(E)-Pentadecenoic acid (1-15 μM; 1 h pre-incubation, followed by 3 days co-incubation with 500 nM α-MSH) dose-dependently inhibits α-MSH-stimulated intracellular tyrosinase activity in B16F10 murine melanoma cells at concentrations of 1, 5, and 15 μM^[1].
10(E)-Pentadecenoic acid (5-15 μM; 1 h pre-incubation, followed by 6 days co-incubation with 500 nM α-MSH) reduces α-MSH-stimulated mRNA expression of TRP-1, TRP-2, and tyrosinase in B16F10 murine melanoma cells at concentrations of 5 and 15 μM^[1].
10(E)-Pentadecenoic acid (5-15 μM; 1 h pre-incubation, followed by 6 days co-incubation with 500 nM α-MSH) reduces α-MSH-stimulated protein expression of TRP-1, tyrosinase, and p-MITF (but not TRP-2) in B16F10 murine melanoma cells at concentrations of 5 and 15 μM^[1].
10(E)-Pentadecenoic acid (5-15 μM; co-incubation with 500 nM α-MSH) inhibits α-MSH-stimulated nuclear translocation of MITF in B16F10 murine melanoma cells at concentrations of 5 and 15 μM^[1].