SIB-1757
CAS No. : 31993-01-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $270 | In-stock |
| 100mg | $380 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-102095 |
| M.Wt: | 213.24 |
| Formula: | C12H11N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C) |
SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM[1].
In Vitro: SIB-1757 (2 μM) reduces the 3,5-DHPG-induced membrane depolarization of the recorded neuron in striatal cholinergic interneurons[4].
In Vivo: SIB-1757 (20 mg/kg, i.p.) reduces the Acetaminophen (HY-66005) induced increased expression and activity of liver iNOS in mice[2].
SIB-1757 (intraplantar injection of 100 μg, or s.c. injection of 20 mg/kg) reverses spinal nerve ligation-induced thermal hyperalgesia in rats[3].
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