D-Isoleucine
CAS No. : 319-78-8
(Synonyms: (R)-Isoleucine)
| Size | Price | Stock |
|---|---|---|
| 100mg | $19 | In-stock |
| 250mg | $44 | In-stock |
| 1g | $145 | In-stock |
| 5g | $525 | In-stock |
| 10g | $836 | In-stock |
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| Cat. No. : | HY-I1070 |
| M.Wt: | 131.17 |
| Formula: | C6H13NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL;H2O : 6.25 mg/mL (ultrasonic;warming;heat to 60°C) |
D-Isoleucine is a selective competitive activator of the Asc-1 antiporter (Ki=0.98 mM). D-Isoleucine promotes the release of D-serine and glycine by binding to the Asc-1 protein on the neuronal cell membrane, and enhances NMDA receptor-dependent synaptic plasticity. D-Isoleucine can be used in the study of neurodegenerative diseases (such as Alzheimer's disease and schizophrenia). D-Isoleucine also acts as a non-classical D-amino acid, interferes with bacterial peptidoglycan synthesis, and inhibits the formation of Staphylococcus aureus biofilm, and has potential antibacterial application value[1][2]. In Vitro: D-Isoleucine (1 mM, 2 mM; 15 min) significantly enhances LTP in hippocampal slices and promotes D-serine release from neurons via activation of Asc-1, which is dependent on NMDA receptors[1]. D-Isoleucine can be identified in the supernatant of Staphylococcus aureus grown in RPMI medium, and can be further used to track the amino acid metabolic footprint of the bacteria[2].
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