L-Homocysteine thiolactone (hydrochloride)
CAS No. : 31828-68-9
| Size | Price | Stock |
|---|---|---|
| 100mg | $77 | In-stock |
| 250mg | $129 | In-stock |
| 1g | $406 | In-stock |
| 5g | $1991 | In-stock |
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| Cat. No. : | HY-101404A |
| M.Wt: | 153.63 |
| Formula: | C4H8ClNOS |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 23 mg/mL;DMSO : 116.67 mg/mL (ultrasonic) |
L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of Homocysteine. Homocysteine thiolactone hydrochloride prevents translational incorporation of homocysteine into proteins. L-Homocysteine thiolactone hydrochloride can induce elevated HHcy (hyperhomocysteinemia) in mice[1][2][3].
In Vitro:L-Homocysteine thiolactone hydrochloride (20 μM; for 24 h) shows significant increase in pro-inflammatory cytokines IP-10, TNFα, IL-1β, and IL6[2].
L-Homocysteine thiolactone hydrochloride (100 μM; for 24 h) shows significantly higher ratios of nuclear/cytoplasmic NF-κB, indicating that Homocysteine (Hcy)-induced NF-κB activation and nuclear translocation[2].
In Vivo:L-Homocysteine thiolactone hydrochloride (1 μL; 200 μM; Intravitreally) induces elevated HHcy (hyperhomocysteinemia)[2]。
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