GW 501516
CAS No. : 317318-70-0
(Synonyms: GW 1516; GSK-516)
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $142 | In-stock |
| 50mg | $204 | In-stock |
| 100mg | $286 | In-stock |
| 250mg | $490 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-10838 |
| M.Wt: | 453.50 |
| Formula: | C21H18F3NO3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
GW 501516 (GW 1516) is a PPARδ agonist with an EC50 of 1.1 nM[1].
IC50 & Target:EC50: 1.1 nM (PPARδ)[1]
In Vitro:GW 501516 is shown to be the most potent and selective PPARδ agonists known with an EC50 of 1.1 nM against PPARδ and 1000-fold selectivity over the other human subtypes, PPARα and-γ[1].
GW 501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx) cells. GW 501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner[3].
In Vivo:GW 501516 causes impaired bone formation, leading to decreased BMD and deterioration of bone properties in OVX rats[2].
GW 501516 attenuates interstitial inflammation and proximal tubular cell damage in a protein-overload mouse nephropathy model[3].
GW 501516 treatment enhances running endurance and the proportion of succinate dehydrogenase (SDH)-positive muscle fibres in both trained and untrained mice[4].
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