Quinupramine
CAS No. : 31721-17-2
(Synonyms: LM 208)
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| Cat. No. : | HY-106578 |
| M.Wt: | 304.43 |
| Formula: | C21H24N2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Quinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system[1][2].
In Vivo: Quinupramine (10 mg/kg, PO, twice daily for 10 days) causes a down-regulation of serotonin S2 receptors in the frontal cortex of the rat[2].
Quinupramine-EVA matrix containing a permeation enhancer can be a good transdermal delivery system for providing sustained plasma concentrations[3].
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