SCH442416
CAS No. : 316173-57-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $52 | In-stock |
| 5mg | $110 | In-stock |
| 10mg | $187 | In-stock |
| 25mg | $396 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $770 | In-stock |
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| Cat. No. : | HY-103169 |
| M.Wt: | 389.41 |
| Formula: | C20H19N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
SCH442416 is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR), with Kis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2A receptors in rat and primate brain[1][2].
IC50 & Target: IC50: 0.048 nM (hA2AR), 0.5 nM (rA2AR)[1]
In Vitro: SCH442416 is selective for A2AR (Ki=0.50 nM) in rat striatal membranes over A1R and A3R (Ki=1815 and >10000, respectively)[1].
SCH442416 (0.1-10 μM) increases the glutamine synthetase (GS) and glutamate aspartate transporter (GLAST) proteins expression of Müller cells in Group 1 μM[5].
In Vivo: SCH-442416 (0.017 mg/kg; i.p.) completely abrogates the CGS-21680-induced decrease in skeletal muscle injury[3].
SCH-442416 (1 μM 2μL; i.v.) increases the GS and GLAST protein expression in rats[5].
SCH442416 (1 μM) significantly attenuates the adenosine-induced dilation (from 15.3 to 5.6 μm)[4].
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