5-Fluorouridine
CAS No. : 316-46-1
| Size | Price | Stock |
|---|---|---|
| 1g | $19 | In-stock |
| 5g | $75 | In-stock |
| 10g | $95 | In-stock |
| 25g | $229 | In-stock |
| 100g | $618 | In-stock |
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| Cat. No. : | HY-107856 |
| M.Wt: | 262.19 |
| Formula: | C9H11FN2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 100 mg/mL (ultrasonic) |
5-Fluorouridine, a metabolite of 5-fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis[1][2][3].
In Vitro: 5-Fluorouridine (167 μM; 24-96 h) inhibits MKN45 cells and MKN28 cells in a time-dependent manner[1].
5-Fluorouridine (10 μM; 24 h; HCT-116 cells) induces apoptosis and increases the percentage of apoptotic cells. 5-Fluorouridine upregulates the expression of 33 genes, including a group of genes as growth factors, cytokines and chemokines (e.g. IL-3, IL -4, B-cell growth factor 1 and stem cell growth factor)[2].
5-Fluorouridine (10 μM; 8-24 h; HCT-116 cells) incorporates into both total and poly A RNA[2].
In Vivo: 5-Fluorouridine (567-1500 mg/kg; i.p.; daily, for 20 d) induce gastrointestinal toxicity in the mice[3].
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