STF-62247
CAS No. : 315702-99-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $41 | In-stock |
| 10mg | $66 | In-stock |
| 25mg | $145 | In-stock |
| 50mg | $251 | In-stock |
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| Cat. No. : | HY-100746 |
| M.Wt: | 267.35 |
| Formula: | C15H13N3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
STF-62247 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively)[1].
In Vitro: In RCC4, RCC4/VHL, SN12C, SN12C-VHL shRNA cells, STF-62247 (0-30 μM) is selectively toxic to VHL-deficient cells compared to their VHL wild-type counterparts[1].
STF-62247-treated cells accumulated intracytoplasmic vacuoles characteristic of cells undergoing autophagy. Moreover, these vacuoles are larger in VHL-deficient RCC4 and SN12C-VHL shRNA cells than in wild-type VHL cells[1].
In Vivo: STF-62247 (2.7-8 mg/kg; intraperitoneal injection; daily; for 9 days) treatment significantly reduces tumor growth of VHL-deficient cells[1].
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