ML311
CAS No. : 315698-17-0
(Synonyms: EU-5346)
| Size | Price | Stock |
|---|---|---|
| 1mg | $47 | In-stock |
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $311 | In-stock |
| 50mg | $466 | In-stock |
| 100mg | $700 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101778 |
| M.Wt: | 415.45 |
| Formula: | C23H24F3N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 67.5 mg/mL (ultrasonic) |
ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction. IC50 & Target:Mcl-1/Bim[1]. In Vitro: ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types[1].
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