1,4-Dihydroxy-2-naphthoic acid

1,4-Dihydroxy-2-naphthoic acid is an aryl hydrocarbon receptor (AhR) agonist. 1,4-Dihydroxy-2-naphthoic acid is also a bacterially derived metabolite and has anti-inflammatory activity^[1]. In Vitro:1,4-Dihydroxy-2-naphthoic acid (25-1000 μM, 18-24 h) induces > 70% of the response for CYP1A1 and CYP1B1 in both YAMC and Caco2 cells^[2].
1,4-Dihydroxy-2-naphthoic acid (100 μM, 24 h) inhibits IL-1β, IL-6, IL-23, p19 and IL-17A mRNA levels in LPS (HY-D1056)-stimulated RAW264.7 cells^[4].
1,4-Dihydroxy-2-naphthoic acid (48-72 h) inhibits proliferation against HaCaT, NCTC 2544, Hs-69 and PIG1 cells with IC₅₀s of 38.94, 46,80, 226.3 and 23.98 μM at 72 h^[5].
1,4-Dihydroxy-2-naphthoic acid (15-120 μM, 9-72 h) induces apoptosis and causes G0/G1 Cell cycle arrest in HaCaT cells in time and dose dependent manners^[5].
1,4-Dihydroxy-2-naphthoic acid (30-240 μM, 24-48 h) decreases MMP, increases DNA fragmentation and causes nuclear translocation of AIF and endoG in HaCaT cells^[5].
1,4-Dihydroxy-2-naphthoic acid (20-100 μM, 72 h) exhibits relatively low skin irritation, that significantly induces the release of IL-1α only at a concentration of 60 μM in NCTC2544cells^[5].
In Vivo:1,4-Dihydroxy-2-naphthoic acid (20 mg/kg, p.o., for 5-10 weeks) successfully prevents and reverses unpredictable chronic mild stress (UCMS)-induced anhedonia-like behavior in mice^[1].
1,4-Dihydroxy-2-naphthoic acid (2 mg/kg, p.o., for 14 days) reduces inflammation in mice with colitis by suppressing macrophage-derived proinflammatory cytokines^[4].
1,4-Dihydroxy-2-naphthoic acid (20 mg/kg, p.o., for 3 weeks) prevents mice motor dysfunction induced by MPTP (HY-W114750)^[6].