Allopurinol
CAS No. : 315-30-0
| Size | Price | Stock |
|---|---|---|
| 25g | $18 | In-stock |
| 100g | $50 | In-stock |
| 500g | $125 | In-stock |
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| Cat. No. : | HY-B0219 |
| M.Wt: | 136.11 |
| Formula: | C5H4N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 14 mg/mL (ultrasonic;warming);H2O : 1 mg/mL (ultrasonic;adjust pH to 11 with NaOH) |
Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 µM. Allopurinol can be used in the treatment of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect[1][2][3][4][5].
In Vitro: Allopurinol (0, 10, 100, 1000 µg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells[5].
Allopurinol (0, 10, 100, 1000 µg/ml; 24 h) reduces angiogenesis traits of HUVEC cells[5].
In Vivo: Allopurinol (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse[3].
Allopurinol (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse[4].
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