Sunifiram


CAS No. : 314728-85-3

(Synonyms: DM-235)

314728-85-3
Price and Availability of CAS No. : 314728-85-3
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5mg $50 In-stock
10mg $80 In-stock
25mg $160 In-stock
50mg $240 In-stock
100mg $360 In-stock
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Cat. No. : HY-17550
M.Wt: 246.30
Formula: C14H18N2O2
Purity: >98 %
Solubility: H2O : 50 mg/mL (ultrasonic);DMSO : ≥ 2.6 mg/mL
Introduction of 314728-85-3 :

Sunifiram (DM-235) is an ampakine-like compound and an agonist of AMPA receptor with oral activity. Sunifiram can increase the release of acetylcholine in the rat cerebral cortex and exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam (HY-B0585). Sunifiram is promising for research in neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's disease (AD)[1][2][3][4]. In Vitro:Sunifiram (0.01-1 μM, 30 minutes) reduced the antagonistic effect of kynurenic acid on NMDA and increased NMDA activity[4]. In Vivo:Sunifiram (0.001-0.1 mg/kg, p.o. or i.v., single dose, 20 minutes prior) is able to prevent amnesia in a scopolamine (HY-N0296)-induced amnesia mouse model[4].

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