Flubendazole
CAS No. : 31430-15-6
| Size | Price | Stock |
|---|---|---|
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| 500mg | $108 | In-stock |
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| Cat. No. : | HY-B0294 |
| M.Wt: | 313.28 |
| Formula: | C16H12FN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 4.17 mg/mL (ultrasonic) |
Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites[1][2].
In Vitro:Flubendazole (0-400 μM; 48 h) inhibits human colorectal cancer (CRC) cells proliferation[1].
Flubendazole (0.3-1.2 μM; 48 h) induces apoptosis in CRC cells[1].
Flubendazole (0.3-1.2 μM; 24 h) induces autophagy initiation by inactivating mTOR and P62, and upregulating LC3-I/II in CRC cells[1].
Flubendazole (0.3-1.2 μM; 24 h) strongly reduces the expression of P-STAT3 in a dose and time-dependent manner[1].
In Vivo:Flubendazole (10, 30 mg/kg; i.p; every other day; 14 days) inhibits growth of CRC tumor xenografts[1].
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