HIOC
CAS No. : 314054-36-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $290 | In-stock |
| 25mg | $650 | In-stock |
| 50mg | $1100 | In-stock |
| 100mg | $1760 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101446 |
| M.Wt: | 301.34 |
| Formula: | C16H19N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration[1][2][3]. In Vivo: HIOC (C57BL/6 mice, 50 mg/kg, IP, three times per week, for two weeks) increased survival of RGCs (retinal ganglion cells) after ONC (optic nerve crush)[3].
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