C-176
CAS No. : 314054-00-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $36 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $100 | In-stock |
| 50mg | $170 | In-stock |
| 100mg | $250 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-112906 |
| M.Wt: | 358.09 |
| Formula: | C11H7IN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic);Ethanol : 2.5 mg/mL (ultrasonic;warming;heat to 60°C) |
C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2].
IC50 & Target:STING[1].
In Vitro:C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6[1].
In Vivo:C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity[1].
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1?/? mice[1].
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1?/? mice[1].
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