FLI-06
CAS No. : 313967-18-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $275 | In-stock |
| 50mg | $440 | In-stock |
| 100mg | $770 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15860 |
| M.Wt: | 438.52 |
| Formula: | C25H30N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 38 mg/mL |
FLI-06 is an inhibitor of Notch signaling with an EC50 of 2.3 μM. IC50 & Target: EC50: 2.3 μM (Notch signaling)[1] In Vitro: FLI-06, disrupted the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibited general secretion at a step before exit from the endoplasmic reticulum. In FLI-06–treated cells, no APPCTF accumulates despite strongly reduced Aβ secretion, suggesting that it acts upstream of α-secretase and β-secretase cleavage. FLI-06 is a very useful chemical probe to study the inhibition of membrane traffic at pre- ER-exit site (ERES) stages without fusion of ER-Golgi[1].
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