PD-118057
CAS No. : 313674-97-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $225 | In-stock |
| 10mg | $335 | In-stock |
| 25mg | $590 | In-stock |
| 50mg | $880 | In-stock |
| 100mg | $1320 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108594 |
| M.Wt: | 386.27 |
| Formula: | C21H17Cl2NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability[1][2].
IC50 & Target:Human ether-a-go-go-related gene channel[1]
In Vitro:PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in guinea pig ventricular muscle in acute isolation of guinea pig cardiomyocytes[2][3].
PD-118057 (10 μM) reverses the current inhibition induced by Dof and Mox without changing the "hump" shape of IKr current recorded by action potential clamp, and only slightly increases the peak value of the suppressed current[3].
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