INH1
CAS No. : 313553-47-8
(Synonyms: IBT13131)
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $110 | In-stock |
| 50mg | $180 | In-stock |
| 100mg | $290 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16660 |
| M.Wt: | 308.40 |
| Formula: | C18H16N2OS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
INH1 specifically disrupts the Hec1/Nek2 interaction via direct Hec1 binding. INH1 shows promising cancer inhibition activity both in vitro and in vivo[1].
In Vitro: INH1 (25 μM, 24 h) treatment resulted in reduced association of Hec1 with kinetochore and decrease of global Nek2 protein level[1].
INH1 exhibits GI50 values of 10.5 μM (in MDA-MB-468 cells), 15 μM (in SKBR3 cells), 10.5 μM (in T47D cells), 20.5 μM (in MDA-MB-361 cells), 15 μM (in ZR-75-1 cells), 15 μM (in HBL 100 cells), 15.5 μM (in MDA-MB-435 cells), 11 μM (in HS578T cells) and 41 μM (in MCF10A cells), respectively[1].
INH1 (5k) has an IC50 value of 176 nM in the dose-dependent transwell migration assays in MDA-MB-231 cells. INH1 (5k) substantially reduces cellular f-actin and prevented localization of fascin to actin-rich membrane protrusions[2].
INH1 induces abnormal mitotic processes, as well as cell apoptosis[3].
In Vivo: INH1 (50 or 100 mg/kg, i.p., every other day/25 cycles) inhibits tumor outgrowth in a xenografted breast cancer model in nude mice[1].
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