CS-526
CAS No. : 313272-12-7
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| Cat. No. : | HY-100413 |
| M.Wt: | 339.41 |
| Formula: | C20H22FN3O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CS-526 is a potent, selective, reversible and orally active acid pump antagonist. CS-526 inhibits H+,K+-ATPase activity. CS-526 inhibits gastric acid secretion and prevents esophageal lesions. CS-526 has the potential for the research of gastroesophageal reflux disease[1].
In Vitro:CS-526 (0-100 µM; 60 min) inhibits H+, K+-ATPase and Na+, K+-ATPase activity in a dose-dependent manner with IC50 values of 61 nM, 10.4 µM, respectively[1].
CS-526 competitive binds to K+ binding site of H+, K+-ATPase[1].
In Vivo:CS-526 (1, 3, 10, 30 mg/kg; intraduodenal or p.o.) inhibits gastric acid secretion in a dose-dependent manner in pylorus-ligated rats[1].
CS-526 (1, 3, 10, 30 mg/kg; intrapouch; 180 min) dose-dependently inhibits the histamine-induced gastric acid secretion in the Heidenhain pouch dogs[1].
CS-526 (1, 3, 10, 30 mg/kg; intraduodenal or p.o.) prevents esophageal lesions and acute gastric mucosal lesions[1].
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