5,6-Dihydroxyindole
CAS No. : 3131-52-0
| Size | Price | Stock |
|---|---|---|
| 250mg | $38 | In-stock |
| 1g | $46 | In-stock |
| 5g | $145 | In-stock |
| 10g | $288 | In-stock |
| 25g | $719 | In-stock |
| 100g | $2373 | In-stock |
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| Cat. No. : | HY-W018025 |
| M.Wt: | 149.15 |
| Formula: | C8H7NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 1 mg/mL (ultrasonic) |
5,6-Dihydroxyindole, a melanin precursor, has a broad-spectrum antibacterial, antifungal, antiviral, antiparasitic activity. 5,6-Dihydroxyindole has cytotoxic effects and is strongly toxic against various pathogens[1].
In Vitro: 5,6-Dihydroxyindole (1, 10, 20, 50, 100 μM; for 4 hours) dose-dependently decreases OD492 values. Pretreatment of Sf9 cells with 1.0 mM 5,6-Dihydroxyindole for 4 hours results in 97% mortality, and LC50 values of 20.3 μM in buffer and 131.8 μM in a culture medium[1].
Preincubation of a baculovirus stock with 1.25 mM 5,6-Dihydroxyindole for 3 hours near fully disables recombinant protein production. The LC50 for lambda bacteriophage and eggs of the wasp Microplitis demolitor are 5.6 and 111.0 μM, respectively[1].
5,6-Dihydroxyindole and its spontaneous oxidation products are also active against viruses and parasitic wasps[1].
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