RS-1


CAS No. : 312756-74-4

312756-74-4
Price and Availability of CAS No. : 312756-74-4
Size Price Stock
5mg $60 In-stock
10mg $82 In-stock
25mg $139 In-stock
50mg $188 In-stock
100mg $255 In-stock
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Cat. No. : HY-19793
M.Wt: 524.23
Formula: C20H16Br2N2O3S
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL
Introduction of 312756-74-4 :

RS-1 is a RAD51 activator. RS-1 enhances the homologous recombination activity of human RAD51 by promoting the formation of active presynaptic filaments[1]. IC50 & Target:RAD51[1][2] In Vitro:RS-1 is a RAD51 activator, stimulating binding of hRAD51 to DNA with Kd ranging from 48 nM to 107 nM in the presence of ATP or ADP and in the absence of a nucleotide cofactor, and such an effect is not via inhibiting its ATPase activity. RS-1 (20 μM) affects the length and helical pitch of hRAD51 protein-DNA complexes. RS-1 (0, 1, 5, 10, 15, 20, and 25 μM) stimulates strand assimilation activity of hRAD51. RS-1 (7.5 μM) promotes resistance of human cells to cross-linking chemotherapy[1]. RS-1 (0, 7.5, 15 μM) increases Cas9-mediated knock-in efficiencies in rabbit embryos[2].

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