10074-A4
CAS No. : 312631-87-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $68 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $504 | In-stock |
| 50mg | $780 | In-stock |
| 100mg | $1209 | In-stock |
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| Cat. No. : | HY-124129 |
| M.Wt: | 409.29 |
| Formula: | C18H14Cl2N2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2].
In Vitro: 10074-A4 shows inhibitory activity of HL-60 cells with an IC50 of 15.1?μM[1].
10074-A4 (25-50 μM; 24 hours) arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells. 10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4[1].
10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain and its binding behavior could be described as a ‘ligand cloud’. Even in the bound state, the structure of the c-Myc370-409 peptide remained a dynamic ensemble. The 10074-A4 ligand bound at different sites throughout the c-Myc370-409 chain with different strength[2].
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