IQ-3
CAS No. : 312538-03-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $99 | In-stock |
| 10mg | $154 | In-stock |
| 25mg | $308 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $825 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-107600 |
| M.Wt: | 341.32 |
| Formula: | C20H11N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively[1].
In Vitro: IQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively[1].
IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells[1].
IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3[1].
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