Thiazesim (hydrochloride)
CAS No. : 3122-01-8
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| Cat. No. : | HY-105857A |
| M.Wt: | 362.92 |
| Formula: | C19H23ClN2OS |
| Purity: | >98 % |
| Solubility: |
Thiazesim hydrochloride is a CNS-penetrant antidepressant agent. Thiazesim hydrochloride depresses amygdala output, disrupts conditioned avoidance response in rats. Thiazesim hydrochloride can be used for the research of depression[1][2][3][4][5].
In Vivo:Thiazesim (1.0-10.0 mg/kg; i.p.) hydrochloride produces no significant reduction in shock-induced defensive fighting, locomotor activity, or shock reactivity in rats[2].
Thiazesim (20 mg/kg; i.p.; daily prior to each acquisition or retention training session) hydrochloride significantly depresses conditioned avoidance response performance in rats during both acquisition and retention phases, without impairing motor escape responses or inducing state-dependent learning[4].
Thiazesim (5-40 mg/kg; i.p.; single dose) hydrochloride blocks all tested unlearned behaviors at nondebilitating doses in rats[5].
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