Hemicholinium 3
CAS No. : 312-45-8
(Synonyms: Hemicholinium (dibromide))
| Size | Price | Stock |
|---|---|---|
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| 10mg | $80 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $280 | In-stock |
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| Cat. No. : | HY-B2152 |
| M.Wt: | 574.35 |
| Formula: | C24H34Br2N2O4 |
| Purity: | >98 % |
| Solubility: | H2O : 33.33 mg/mL (ultrasonic) |
Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh)[1]. Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively[2].
In Vitro: Hemicholinium 3 (HC-3) inhibits the presynaptic nicotinic acetylcholine receptors of myenteric neurons. HC-3 inhibits nAChRs located on the terminal region of myenteric neurons of guinea-pig longitudinal muscle strip preparation[2].
Hemicholinium 3 (HC-3) inhibits[3H]choline uptake with the Ki value of 13.3 μM in NCI-H69 cells[3].
HC-3 (1 mM) significantly inhibits cell viability and increases caspase-3/7 activity in NCI-H69 cells[3].
Hemicholinium 3 (Hemicholinium-3) inhibits sodium dependent high affinity choline uptake (IC50=18 nM)[4].
In vivo：
In Vivo: Hemicholinium-3 impairs spatial learning. HC-3 (2.5, 5.0 μg/rat/ICV; 1 h before training) dose dependently impairs spatial learning[5].
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