RFRP-3(human)
CAS No. : 311309-27-0
(Synonyms: Neuropeptide VF(124-131)(human); Neuropeptide NPVF (human))
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $175 | In-stock |
| 10mg | $265 | In-stock |
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| Cat. No. : | HY-P1250 |
| M.Wt: | 969.14 |
| Formula: | C45H72N14O10 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1]. In Vitro: RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1]. Scatchard-plot analysis shows that 125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kd value and the Bmax values are 0.19 nM and 1.3 pM, respectively.RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1].RFRP-3 (10-8 to 10-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination[1].
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