RFRP-1(human)
CAS No. : 311309-25-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $72 | In-stock |
| 5mg | $180 | In-stock |
| 10mg | $270 | In-stock |
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| Cat. No. : | HY-P1428 |
| M.Wt: | 1428.70 |
| Formula: | C67H101N19O14S |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively[1][2][3].
In Vivo: RFRP-1(human) rapidly and reversibly decreases shortening and relaxation in isolated mammalian cardiac myocytes in a dose dependent manner[2].
Intravenous injection of RFRP-1(human) in mice decreases heart rate, stroke volume, ejection fraction, and cardiac output[2].
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