Tubulysin D
CAS No. : 309935-57-7
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| Cat. No. : | HY-N2348 |
| M.Wt: | 828.07 |
| Formula: | C43H65N5O9S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2]. IC50 & Target: IC50: 1.7 μM (Tubulin)[1] In Vitro: Tubulysin D has IC50s of 4.7 pM, 3.1 pM, 670 pM and 13 pM for HL60, HCT116, MCF7, A549 cell lines antiproliferative activity, respectively[1].
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