SX 011
CAS No. : 309913-42-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $364 | In-stock |
| 10mg | $546 | In-stock |
| 25mg | $1090 | In-stock |
| 50mg | $1640 | In-stock |
| 100mg | $2460 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108646 |
| M.Wt: | 483.96 |
| Formula: | C26H27ClFN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SX 011 is a p38 inhibitor with IC50s of 9 nM and 90 nM against p38α and p38β, respectively. SX 011 also inhibits JNK-2 with an IC50 of 100 nM. SX-011 is orally bioavailable[1]. In Vitro:SX-011 inhibits LPS stimulated TNFα and interleukin-1β (IL-1β) from human peripheral blood mononuclear cells (PBMC) with an IC50 of 200 nM and 900 nM, respectively. Additionally, IL-6 (IC50 250 nM) and IL-8 (IC50 100 nM) are significantly inhibited in this assay[2]. In Vivo:SX-011 is orally bioavailable in preclinical species (rat, 24%; monkey, 29%; dog, 43%) and has demonstrated efficacy in both acute and chronic models of inflammation in rats. Rat t1/2 = 30 min[1][2].
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