LMP744 (hydrochloride)
CAS No. : 308246-57-3
(Synonyms: MJ-III65 (hydrochloride); NSC706744 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $290 | In-stock |
| 10mg | $450 | In-stock |
| 50mg | $1100 | In-stock |
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| Cat. No. : | HY-U00248A |
| M.Wt: | 488.92 |
| Formula: | C24H25ClN2O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 105 mg/mL (ultrasonic) |
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].
IC50 & Target: Top1[1].
In Vitro: The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[2].
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].
In Vivo: LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].
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