GRA Ex-25
CAS No. : 307983-31-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $139 | In-stock |
| 10mg | $211 | In-stock |
| 25mg | $422 | In-stock |
| 50mg | $633 | In-stock |
| 100mg | $950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-50675 |
| M.Wt: | 563.61 |
| Formula: | C29H36F3N3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 32 mg/mL |
GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. IC50 & Target: IC50: 56 nM (rat glucagon receptor), 55 nM (human glucagon receptor)[2] In Vitro: GRA Ex-25 binds a human glucagon receptor (h-GlucRbind) with Ki of 63 nM and a moderate glucagon induced adenylate cyclase inhibition (h-GlucRcyclase) with Ki of 254 nM under our assay conditions[1]. GRA Ex-25 has similar affinity to the rat and human glucagon receptors (IC50=56 and 55 nM, respectively)[2]. In Vivo: GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose caused by exogenous administration of glucagon in rat model. GRA Ex-25 is able to inhibit the rise in blood glucose levels elicited by exogenous administered glucagon, most likely because of the direct inhibition of glucagon stimulated hepatic glucose output[2].
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