PD173952
CAS No. : 305820-75-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $251 | In-stock |
| 10mg | $410 | In-stock |
| 25mg | $820 | In-stock |
| 50mg | $1312 | In-stock |
| 100mg | $2100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122113 |
| M.Wt: | 482.36 |
| Formula: | C24H21Cl2N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2].
In Vitro:PD173952 (0-1000 nM; 12 h) inhibits tyrosine phosphorylation of p210Bcr-Abl and CrkL in K562 cells in a concentration-dependent manner[1].
PD173952 (0.5 μM; 1-4 days) inhibits K562 cell viability[1].
PD173952 (0.5 μM; 24 and 48 h) induces apoptosis of K562 and MEG-01 cells[1].
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