Geldanamycin
CAS No. : 30562-34-6
| Size | Price | Stock |
|---|---|---|
| 10mg | $50 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $150 | In-stock |
| 100mg | $250 | In-stock |
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| Cat. No. : | HY-15230 |
| M.Wt: | 560.64 |
| Formula: | C29H40N2O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.
IC50 & Target:Kd: 1.2 μM (Hsp90)[4]
In Vitro: Geldanamycin significantly delays and reduces viperin expression, indicating that IRF3 is involved in viperin induction in RAW264.7 cells[1].
Geldanamycin, a benzoquinone ansamycin, protected against neuronal injury induced by oxygen-glucose deprivation (OGD)/zVAD treatment in cultured primary neurons. More importantly, Geldanamycin decreases RIP1 protein level in a time and concentration-dependent manner. Geldanamycin also decreases the Hsp90 protein level, which causes instability of RIP1 protein, resulting in decreased RIP1 protein level but not RIP1 mRNA level after Geldanamycin treatment[2].
Geldanamycin is identified as the first natural product inhibitor of Hsp90 that binds to the N-terminal ATPase domain of Hsp90 to inhibit its chaperone function, and significantly induces tumor cell death via an apoptotic mechanism[3].
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