Stavudine
CAS No. : 3056-17-5
(Synonyms: d4T)
| Size | Price | Stock |
|---|---|---|
| 100mg | $10 | In-stock |
| 1g | $15 | In-stock |
| 5g | $20 | In-stock |
| 10g | $39 | In-stock |
| 25g | $80 | In-stock |
| 100g | $220 | In-stock |
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| Cat. No. : | HY-B0116 |
| M.Wt: | 224.22 |
| Formula: | C10H12N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : 16.67 mg/mL (ultrasonic) |
Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4]. In Vitro:Stavudine (d4T) (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages[3].
Stavudine (d4T) (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages[3].
Stavudine (d4T) (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels[4].
In Vivo:Stavudine (d4T) (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice[5].
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