SANT-1
CAS No. : 304909-07-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $61 | In-stock |
| 10mg | $99 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $275 | In-stock |
| 100mg | $495 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100224 |
| M.Wt: | 373.49 |
| Formula: | C23H27N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively[1].
IC50 & Target:IC50: 20 nM (Shh signaling), 30 nM (SmoA1)[1]
In Vitro:SANT-1 is a potent Smo antagonist, binds directly to Smo, and inhibits Hedgehog signaling, with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 cells, respectively[1].
SANT-1 (1 μM, for 24 or 48 hours) decreases the proliferation of medulloblastoma cells[2].
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