Flunarizine (dihydrochloride)
CAS No. : 30484-77-6
| Size | Price | Stock |
|---|---|---|
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| 1g | $75 | In-stock |
| 5g | $160 | In-stock |
| 10g | $260 | In-stock |
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| Cat. No. : | HY-B0358A |
| M.Wt: | 477.42 |
| Formula: | C26H28Cl2F2N2 |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects[1][2][3][4][5].
In Vitro:Flunarizine blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 μM and 1.77 μM in cultured rat cortical neurons, respectively[2].
Flunarizine (10 and 30 μM; 24 h) shows cytotoxic effects to chromaffin cells[4].
Flunarizine (1-30 μM) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 μM[4].
In Vivo:Flunarizine (intraperitoneal injection; 30 mg/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI)[5].
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