Lu AA33810
CAS No. : 304008-29-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $136 | In-stock |
| 5mg | $340 | In-stock |
| 10mg | $545 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-107729 |
| M.Wt: | 423.62 |
| Formula: | C19H25N3O2S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 42.36 mg/mL (ultrasonic;warming) |
Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects[1][2].
In Vitro:Lu AA33810 antagonizes NPY-evoked cAMP and calcium mobilization in vitro[1].
In Vivo:In Sprague-Dawley rats subjected to the social interaction test, Lu AA33810 (3-30 mg/kg p.o.) produces anxiolytic-like effects after acute or chronic treatment[1].
In Flinders sensitive line rats, chronic dosing of Lu AA33810 (10 mg/kg/day i.p.) produces anxiolytic-like effects in the social interaction test, plus antidepressant-like effects in the forced swim test[1].
In Wistar rats exposed to chronic mild stress, chronic dosing of Lu AA33810 (3 and 10 mg/kg/day i.p.) produces antidepressant-like activity, i.e., normalization of stress-induced decrease in sucrose consumption[1].
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