MitoBloCK-6
CAS No. : 303215-67-0
| Size | Price | Stock |
|---|---|---|
| 25mg | $95 | In-stock |
| 50mg | $155 | In-stock |
| 100mg | $250 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-122652 |
| M.Wt: | 357.23 |
| Formula: | C19H14Cl2N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming) |
MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce Apoptosis via cytochrome c release. MitoBloCK-6 inhibits growth of developing zebrafish motor neurons. MitoBloCK-6 has anticancer activity against liver cancer and leukemia[1][2][3][4][5][6].
IC50 & Target:IC50: 900 nM (Erv1) 700 nM (ALR) 1.4 μM (Erv2)[1]
In Vitro:MitoBloCK-6 (20 μM, 8 h) induces apoptosis via cytochrome c release in human embryonic stem cells (hESCs)[1].
MitoBloCK-6 (20-40 μM, 72 h) inhibits proliferation of liver cancer cells McA-RH7777 via mitochondrial impairment[2].
MitoBloCK-6 kills leukemia cell lines (OCI-AML2, TEX, Jurkat and NB4) with an IC50 of 5-10 µM[3].
MitoBloCK-6 (0.078-5 μM) increases the differentiation of OCI-AML2 and NB4 cells via inhibition of ALR, as increased surface expression of the myeloid markers CD11b[4].
MitoBloCK-6 results in a significant decrease in the growth and branching of developing zebrafish motor neurons via inhibition of ALR[5].
In Vivo:MitoBloCK-6 (80 mg/kg, i.p., 5 of 7 days, twice daily) reduces tumor growth and the engraftment of AML cells into the marrow in mice xenografted with OCI-AML2 cells[4].
MitoBloCK-6 (80 mg/kg i.p. 5 of 7 days, 2 weeks) strongly reduces the engraftment of primary AML cells in mice[6].
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