SR0987


CAS No. : 303126-97-8

303126-97-8
Price and Availability of CAS No. : 303126-97-8
Size Price Stock
5mg $65 In-stock
10mg $109 In-stock
25mg $240 In-stock
50mg $400 In-stock
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Cat. No. : HY-101454
M.Wt: 397.70
Formula: C16H10ClF6NO2
Purity: >98 %
Solubility: DMSO : ≥ 150 mg/mL
Introduction of 303126-97-8 :

SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1[1]. IC50 & Target: EC50: 800 nM (RORγt)[1]. In Vitro: SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production[1].

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